Researchers of VTT, the University of Turku and the University of Heidelberg discover new information on spreading of cancer
A joint research group of VTT Technical Research Centre of Finland and the University of Turku, led by Professor Johanna Ivaska, has discovered a mechanism lung cancer cells use when spreading into the body to form metastases. The study has been published in Science Signaling on 30th June 2009. In cooperation with the University of Heidelberg, they have also found a factor controlling the spreading of several different cancer types. The common feature in both findings is that they explain the lethal ability of cancer cells to “start running” and spread from the original tumour to other parts of the body.
Cancer is lethal because of its ability to spread into the body to form metastases. Previously, it was thought that spreading cancer cells lose the factors that bind them to other cells of the tumour, and this enables the cells to detach and migrate within the body.
Videos made by the research group’s PhD student Saara Tuomi on migrating lung cancer cells revealed to the group that the cells move using their adhesion receptors in a manner that was previously unknown. The new finding of the research group reveals that cancer cells are able to change in such a manner that a factor that previously assisted them in staying in place starts to assist the cells’ adhesion receptors and is thus the precondition needed by the cells to migrate. The group found evidence suggesting that the tumours of lung cancer patients who died because of metastases had cells that started moving using this previously unknown mechanism.
The finding opens new opportunities for the development of medicine because the migration mechanism is not vital for normal cells. The research results have been published on 30 June 2009 in the cellular biology journal Science Signaling, daughter journal of the top scientific journal Science.
The research group led by Professor Johanna Ivaska found in cooperation with researchers of the University of Heidelberg a new factor that controls the appearance of cancer cell adhesion receptors in several cancer types. The new protein has been named SCAI. The name means a cancer invasion inhibitor. The research shows that many cancers are able to eliminate the suppressing factor. This result is the cancer adding the number of its adhesion receptors on the surface of the cells and starting effective spreading. Thus, the fact that the suppressing factor is eliminated makes it possible for the cancer to spread. The research results were published in May 2009 in top scientific journal Nature Cell Biology.
When combined, these findings increase the understanding of how cancer spreads and may influence future trends in cancer research.
Figure: A cancer cell starting to run, detaching itself from the rest of the tumour (High resolution)
Video: Video shows how lung cancer cells move in a cell culture dish. Similar movement is allegedly a prerequisite for the spreading of the cancer also in human organism. Joint research group of VTT and the University of Turku have found a mechanism that regulates the ability of these cells to move as seen in the video. On the grounds of the findings cancer cells can now be treated to prevent the movement. (The video is in .mov-format, which requires e.g. QuickTime-player)
Tuomi, S., Mai, A., Nevo, J., Öhman, T.J., Gahmberg, C.G., Parker, P.J. and Ivaska, J. (2009) PKCe regulation of an a5 integrin-ZO-1 complex controls lamellae formation in migrating cancer cells. Sci. Signal. 2, ra32 (2009).
Brandt DT, Baarlink C, Kitzing TM, Kremmer E, Ivaska J, Nollau P, Grosse R. (2009) SCAI acts as a suppressor of cancer cell invasion through the transcriptional control of b1-integrin. Nat Cell Biol. 2009 May; 11(5): 557-68.
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