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Thesis: Genetic regulatory networks in avian B cells

20.12.2010


The science of systems biology seeks to understand the genetic networks that govern organism development and functions. Research Scientist Pekka Kohonen from VTT and the University of Turku presented his doctoral dissertation “Genetic regulatory networks in avian B cells" in the University of Turku on 1st October 2010.

Pekka Kohonen

In this study the chicken was used as a model organism in the study of B cell regulatory factors. These studies open new avenues for plasma cell research by connecting the down regulation of the B cell gene expression program directly to the initiation of plasma cell differentiation.

This study highlighted the opportunities afforded by the genome sequencing efforts and somatic cell reverse genetics approaches using the DT40 cell line. The DT40 cell line and the avian model system promise to remain a fruitful model for mechanistic insight in the post-genomic era as well.

Dissertation: Genetic regulatory networks in avian B cells: https://www.doria.fi/handle/10024/63732


Additional information

Pekka Kohonen
Research Scientist
+358 20 722 2861

 

 

Additional information

Pekka Kohonen
Research Scientist
+358 20 722 2861