Thesis: Genetic regulatory networks in avian B cells
The science of systems biology seeks to understand the genetic networks that govern organism development and functions. Research Scientist Pekka Kohonen from VTT and the University of Turku presented his doctoral dissertation “Genetic regulatory networks in avian B cells" in the University of Turku on 1st October 2010.
In this study the chicken was used as a model organism in the study of B cell
regulatory factors. These studies open new avenues for plasma cell research by
connecting the down regulation of the B cell gene expression program directly
to the initiation of plasma cell differentiation.
This study highlighted the opportunities afforded by the genome sequencing efforts and somatic cell reverse genetics approaches using the DT40 cell line. The DT40 cell line and the avian model system promise to remain a fruitful model for mechanistic insight in the post-genomic era as well.
Dissertation: Genetic regulatory networks in avian B cells: https://www.doria.fi/handle/10024/63732
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