Team leader
Prof. Jan Jan Borén, PhD
The Wallenberg Laboratory
Sahlgrenska University Hospital
SE413 45 Göteborg
Sweden
Email: jan.boren@wlab.gu.se

University of Gothenburg is the largest university in Scandinavia. The Sahlgrenska Academy at the University of Gothenburg has a long-standing focus and a strong international reputation in metabolic and cardiovascular diseases.

Dr. Jan Borén investigates the role of apoB-containing lipoproteins in lipid physiology and elucidates the molecular mechanism by which the apoB-containing lipoproteins induce atherosclerosis. The team uses a wide range of technologies such as expression analysis, conventional and conditional gene targeting in mice, gene transfer, laser-capture microdissection, cell sorting, mass-spectrometry-based lipid analysis, biochemistry, cell biology, computer modelling, and bioinformatics.

Key people in the team

  • Dr. Jan Borén, Professor in cardiovascular research

  • Dr. Sven-Olof Olofsson, Professor of cardiovascular biochemistry

  • Dr. Martin Adiels, multicompartment modelling

  • Thomas Larsson, proteomics and lipid analysis

Selected publications

  • Adiels M, Taskinen MR, Packard C, Caslake MJ, Soro-Paavonen A, Westerbacka J, Vehkavaara S, Hakkinen A, Olofsson SO, Yki-Jarvinen H, Boren J. Overproduction of large VLDL particles is driven by increased liver fat content in man. Diabetologia 49, 755-765 (2006).

  • Adiels M, Westerbacka J, Soro-Paavonen A, Hakkinen AM, Vehkavaara S, Caslake MJ, Packard C, Olofsson SO, Yki-Jarvinen H, Taskinen MR, Boren J. Acute suppression of VLDL(1) secretion rate by insulin is associated with hepatic fat content and insulin resistance. Diabetologia 50, 2356-2365 (2007).

  • Gustafsson M, Levin M, Skalen K, Perman J, Friden V, Jirholt P, Olofsson SO, Fazio S, Linton MF, Semenkovich CF, Olivecrona G, Boren J. Retention of low-density lipoprotein in atherosclerotic lesions of the mouse: evidence for a role of lipoprotein lipase. Circ Res 101, 777-783 (2007).

  • Bostrom P, Andersson L, Rutberg M, Perman J, Lidberg U, Johansson BR, Fernandez-Rodriguez J, Ericson J, Nilsson T, Boren J, Olofsson SO. SNARE proteins mediate fusion between cytosolic lipid droplets and are implicated in insulin sensitivity. Nat Cell Biol 9,1286-1293 (2007).

  • Adiels M, Olofsson SO, Taskinen MR, Boren J. Overproduction of VLDL particles is the hallmark of the dyslipidemia in the metabolic syndrome. Arterioscler Thromb Vasc Biol. In Press.