Dr. Serge Rezzi
Nestlé Research Center
1000 Lausanne 26
As part of Nestlé, international food, nutrition and well being company, the
Nestlé Research Center (NESTEC) covers a wide range of expertise in nutrition,
immunology, allergy, microbiology, biochemistry, food science, food quality
and safety and nutrigenomics technologies. The NESTEC employs over 500
scientists and technicians.
The team has a unique expertise in metabolic analysis using the metabonomics
approach. Metabonomics research addresses the metabolic understanding of human
with foods and its consequences in health maintenance. The main scientific
goal is to characterize the metabolic health of individuals in relation with
dietary patterns and environmental factors. This is particularly carried out
through the metabolic determination of the complex metabolic interactions
between gut microbiota and host physiological processes. The "Metabonomics and
Biomarkers" group of NRC comprises fifteen senior scientists, post-doctoral
fellows, research students and technical support. From a technological aspect,
the group has access to two high resolution NMR (600MHz) spectrometers and
various MS instruments (UPLC-TOF-MS, GC/GC-TOF-MS, HPLC-MSn, GC-MS, GC-IRMS,
HPLC-IRMS). Furthermore, the team is composed by biologists, microbiologists,
analytical chemists and statisticians, which is unique in joining
complementary expertise for data generation, analysis and biochemical
Key people in the team
Martin FP, Wang Y, Sprenger N, Yap IK, Lundstedt T, Lek P, Rezzi S, Ramadan Z,
van Bladeren P, Fay LB, Kochhar S, Lindon JC, Holmes E, Nicholson JK,
Probiotic modulation of symbiotic gut microbial-host metabolic interactions in
a humanized microbiome mouse model. Mol Syst Biol 4, e157 (2008).
Rezzi S, Ramadan Z, Martin FP, Fay LB, van Bladeren P, Lindon JC, Nicholson
JK, Kochhar S, Human metabolic phenotypes link directly to specific dietary
preferences in healthy individuals. J Proteome Res 6, 4469-4477 (2007).
Kochhar S, Jacobs DM, Ramadan Z, Berruex F, Fuerholz A, Fay LB, Probing
gender-specific metabolism differences in humans by nuclear magnetic
resonance-based metabonomics. Anal Biochem 352, 274-281 (2006).
Martin FP, Dumas ME, Wang Y, Legido-Quigley C, Yap IK, Tang H, Zirah S, Murphy
GM, Cloarec O, Lindon JC, Sprenger N, Fay LB, Kochhar S, van Bladeren P,
Holmes E, Nicholson JK, A top-down systems biology view of
microbiome-mammalian metabolic interactions in a mouse model. Mol Syst Biol 3,
Wang Y, Lawler D, Larson B, Ramadan Z, Kochhar S, Holmes E, Nicholson JK,
Metabonomic investigations of aging and caloric restriction in a life-long dog
study. J Proteome Res 6, 1846-1854 (2007).