Prof. Marta Cascante, PhD
Biochemistry and Molecular Biology
Avda Diagonal 645
Nou, pltes -1, -2
08028, Barcelona, SPAIN
The U. of Barcelona is a public University (65000 students and 5000 R&D
personnel) whose basic activities are higher education and scientific
research. UB manages about 150 European projects per year. Dept. of
Biochemistry and Mol. Biol. at Faculty of Biology has an excellent range of
facilities for systems biology andin particular for metabolic profile and
The team has extensive experience in modelling biological processes relevant
to different pathologies in the framework of translational research projects.
Prof. Cascante has been the pioneer in contributing to the development of
Metabolic Control Analysis (MCT or MCA) within the framework of Systems
Biology. Nowadays the team is developing new in silico tools to integrate
kinetic and experimental data obtained in tracer-based metabolomics in models
of altered cell metabolism, which have proved to be very useful for the
analysis and understanding of metabolic network regulation. Furthermore, in
the last years the team has developped and applied methods for metabolic flux
quantification in different cellular models. Centralized supercomputing
platforms will be available to the project. Supercomputing facilites,
appropiate software as well as bioinformatics expertise and technical support
are available in our research team to support biological process modelling
required in this project.
Key people in the team
Marta Cascante, Dr, Full Professor, Systems Biology-Metabolomics
Vitaly Selivanov, Dr, Scientist, Bioinformatics-Metabolomics-Modelling
Silvia Marin, Dr, Scientist, Metabolomics-Bioinformatics
Josep Centelles, Dr, Professor, Biochemistry
Pedro de Atauri, Dr, Scientist, Modelling-Bioinformatics
Vizán P, Alcarraz-Vizán G, Díaz-Moralli S, Rodríguez-Prados JC, Zanuy M,
Centelles JJ, Jáuregui O, Cascante M, Quantification of intracellular
phosphorylated carbohydrates in HT29 human colon adenocarcinoma cell line
using liquid chromatography-electrospray ionization tandem mass spectrometry.
Anal Chem 79, 5000-5005 (2007).
Selivanov VA, Krause S, Roca J, Cascante M, Modeling of spatial metabolite
distributions in the cardiac sarcomere. Biophys J 92, 3492-3500 (2007).
Lizarraga D, Lozano C, Briedé JJ, van Delft JH, Touriño S, Centelles JJ,
Torres JL, Cascante M, The importance of polymerization and galloylation for
the antiproliferative properties of procyanidin-rich natural extracts. FEBS J
274, 4802-4811 (2007).
Selivanov VA, Marin S, Lee PW, Cascante M, Software for dynamic analysis of
tracer-based metabolomic data: estimation of metabolic fluxes and their
statistical analysis. Bioinformatics 22, 2806-2812 (2006).
de Atauri P, Ramírez MJ, Kuchel PW, Carreras J, Cascante M, Metabolic
homeostasis in the human erythrocyte: in silico analysis. Biosystems 83,