Team leader
Dr. Antonio Vidal-Puig
Metabolic Research Laboratories
Level 4, Institute of Metabolic Science
Box 289, Addenbrooke's Hospital
Phone : +44 1223762790

Dr. Antonio Vidal-Puig is a Reader in Metabolic Medicine and Honorary Consultant in Metabolic Medicine at the University of Cambridge. Currently he is the Deputy Director of the MRC Center for Obesity Research and associated Diseases (MRC-CORD) and Director of the Mouse program of the Wellcome Trust Integrative Physiology Program. Areas of expertise include adipocyte biology, mitochondrial biology, lipotoxicity and genetically modified mouse models.

Key people in the team

  • Stefania Carrobio

  • Sergio Rodriguez

  • Janice Carter, senior animal technician

Selected publications

  • Yetukuri L, Katajamaa M, Medina-Gomez G, Seppänen-Laakso G, Vidal Puig A, Orešič M, Bioinformatics strategies for lipidomics analysis: characterization of obesity related hepatic steatosis. BMC Syst Biol 1, e12 (2007).

  • Medina-Gomez G, Gray S, Yetukuri L, Shimomura K, Virtue S, Campbell M, Curtis K, Jimenez-Linan M, Blount M, Yeo GSH, Lopez M, Seppänen-Laakso T, Ashcroft FM, Orešič M, Vidal-Puig A, PPAR gamma 2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism. PLoS Genet 3, e64 (2007).

  • Lelliott CJ, Medina-Gomez G, Petrovic N, Kis A, Feldmann HM, Bjursell M, Parker N, Curtis K, Campbell M, Hu P, Zhang D, Litwin SE, Zaha VG, Fountain KT, Boudina S, Jimenez-Linan M, Blount M, Lopez M, Meirhaeghe A, Bohlooly YM, Storlien L, Stromstedt M, Snaith M, Oresic M, Abel ED, Cannon B, Vidal-Puig A, Ablation of PGC-1beta results in defective mitochondrial activity, thermogenesis, hepatic function, and cardiac performance. PLoS Biol 4, e369 (2006).

  • Gray SL, Nora ED, Grosse J, Manieri M, Stoeger T, Medina-Gomez G, Burling K, Wattler S, Russ A, Yeo GS, Chatterjee VK, O'Rahilly S, Voshol PJ, Cinti S, Vidal-Puig A, Leptin deficiency unmasks the deleterious effects of impaired peroxisome proliferator-activated receptor gamma function (P465L PPARgamma) in mice. Diabetes 55, 2669-2677 (2006).

  • Medina-Gomez G, Virtue S, Lelliott C, Boiani R, Campbell M, Christodoulides C, Perrin C, Jimenez-Linan M, Blount M, Dixon J, Zahn D, Thresher RR, Aparicio S, Carlton M, Colledge WH, Kettunen MI, Seppanen-Laakso T, Sethi JK, O'Rahilly S, Brindle K, Cinti S, Oresic M, Burcelin R, Vidal-Puig A, The link between nutritional status and insulin sensitivity is dependent on the adipocyte-specific peroxisome proliferator-activated receptor-gamma2 isoform. Diabetes 54, 1706-1716 (2005).