Team leader
Dr. Oleg Demin, CSO of Institute for Systems Biology SPb
AN Belozersky IPCB
Moscow State University
CSO Institute for Systems Biology SPb
Leninskie Gory
Moscow, Russia,119992
Phone: +7 495 783 8718, Fax : +7 495 783 8718

The Institute for Systems Biology SPb is SME which has been established in 2004. Basic activities of ISBSPb are scientific research in areas of Systems Biology and Bioinformatics and scientific programming with focus on quantitative description of biological processes and their application to biotechnology and biomedicine.

All personnel of ISBSPb are highly experienced in development of kinetic models based on all possible experimental data available and reconstruction of dynamic and regulatory behavior of the biochemical systems from both bacteria (E.coli, M.tuberculosis, S.pneumoniae) and eukaryotes (yeast, hepatocyte, platelet, endothelium cell, cardiomyocyte, osteoblast, osteoclast). Kinetic models of most of the metabolic pathways of central E.coli metabolism have been developed including glycolysis, gluconeogenesis, Krebs cycle, glyoxilate shunt, pentose phosphate pathway, pathways of amino acids and nucleotide biosynthesis. Signaling pathways initiated by epidermal growth factor, parathyroid hormone, prostaglandins, tumor necrosis factor etc. in hepatocyte, platelet, endothelium cell, osteoblast and osteoclast have been reconstructed and modelled. Mathematical models of gene regulatory pathways in both bacteria (E.coli central catabolism, purine biosynthesis etc) and mammals (NFkB regulated gene expression etc.) have been built and studied. Kinetic models of organelles (mitochondria, chloroplasts) describing their bioenergetics have been constructed and verified against available experimental data. These models have been applied to resolve different problems arising in areas of biotechnology (strain improvements, optimization of biotechnological processes) and biomedicine (drug discovery, drug safety, drug development).

Key people in the team

  • Dr. Oleg Demin

  • Dr. Ekaterina Mogilevskaya

  • Dr. Sergey Smirnov

  • Dr. Yuri Kosinsky

  • Dr. Eugeniy Metelkin

  • Dr. Ekaterina Goryacheva

  • Dr. Kirill Peskov

  • Dr. Tatiana Karelina

Selected publications

  • Ma H, Sorokin A, Mazein A, Selkov A, Selkov E, Demin OV, Goryanin II, The Edinburgh human metabolic network reconstruction and its functional analysis, Mol Syst Biol 3, 1-8 (2007).

  • Mogilevskaya EA, Lebedeva GV, Gorianin II, Demin OV, A kinetic model of functioning and regulation of Escherichia coli isocitrate dehydrogenase. Biofizika 52, 47-56 (2007).

  • Metelkin EA, Goryanin II, Demin OV, Mathematical modeling of mitochondrial adenine nucleotide translocase. Biophys J 90, 423-432 (2006).

  • Goryanin II, Lebedeva GV, Mogilevskaya EA, Metelkin EA, Demin OV, Cellular kinetic modeling of the microbial metabolism. Methods Biochem Anal 49, 437-488 (2006).